Monday, 2 July 2007

Simple Creatures, Intriguing Finds

Researchers look to fruit flies and tiny worms for greater understanding of neurodegenrative diseases such as Alzheimer's and Parkinson's. Fruit flies have many genes in common with higher animals, including humans. Researchers can easily transplant genes from humans into fruit flies. Finding mutations and observing the characteristics they produce are easier in fruit flies than in other types of animals.
Feany’s laboratory has bred a strain of the fruit fly Drosophila melanogaster that models Parkinson’s disease. Her team implanted mutant genes in the flies for a protein called alpha-synuclein.
Flies carrying the mutant genes lose dopamine-producing neurons in the brain’s substantia nigra, just as humans with Parkinson’s do. Also, fibrous bundles of alpha-synuclein form in the insects’ neurons. Bundles of the same structure and composition (called Lewy bodies) develop in the brain cells of people with Parkinson’s.
Cellular changes in the flies correlate with behavioral changes. Normal fruit flies climb up the sides of plastic vials. Middle-aged flies carrying the transplanted, mutant gene lose that ability.

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